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Prolonged or repeated stress exposure has often been associated with altered cortisol dynamics and may precipitate a cascade of neurobiological changes, including increased neuroinflammatory activity, persistent oxidative stress, dysregulation of key neurotransmitter systems, and structural as well as functional abnormalities within the hippocampus

In this study, the two ferroptosis-inhibiting factors, including GPX4 and FTH1, were significantly elevated in the chronic tophi, while the expression of the ferroptosis-promoting factor ALOX15 in acute joint cavity effusion was significantly higher than in chronic tophi

Last reviewed: June 2026 Medical disclaimer: This article provides general information only and is not a substitute for personalised medical advice

(2008) and Salama et al