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The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default

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This myeloid-driven TGF-1-mediated suppression likely influences the regulatory B cell phenotype observed, which limits their capacity to stimulate T cells and form functional TLS (63, 64)