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Med ., 2014, vol

N Engl J Med 312, 159163 (1985) 61

Tricarballylic acid is also a competitive inhibitor of aconitate hydratase , with a K i value of 0.52 mM

Both MMF and fumarate are believed to be responsible for the primary therapeutic effects of DMF through activation and inhibition of the transcription factors, Nrf2 ( via the agonism of the hydroxycarboxylic acid receptor 2 ( in vitro and in vivo immunologic actions of DMF ( in vitro causes a rise in the concentration of succinate ( in vivo by using global metabolomics profiling of blood plasma of patients with relapsing-remittent multiple sclerosis treated for 6 weeks with DMF