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Over transferrin bound (TBI) and non-transferrin bound iron (NTBI) can overwhelm the heavy chain ferritin (FtH) capacity, which lead to release of labile iron and render proximal tubular epithelial cells (PTEC) susceptible to iron oxidant damage, especial in distal tubular epithelial cells (DTEC) with lack iron storage (light and heavy chain ferritin) and export protein (ferroportin) (48)

Together, this multi-layer remodeling across the PFC, NAc, amygdala, and hippocampus provides a mechanistic bridge linking depressive and addictive pathology (Fig

Notes: metformin can result in due to its effect to block gluconeogenesis, which can impair the hepatic metabolism of lactic acid lactic acidosis Considered a (hypoglycemia does not occur) euglycemic Figure 3