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Additionally, the upregulation of inflammation-related genes, such as IL-6 and TNF-, is associated with the pathological state of depression, suggesting that immune responses play a critical role in its pathogenesis [365, 366]

Safety and toxicity data are lacking for lipophilic (hydrophobic) garlic preparations, but some of their constituents have been shown to interfere with drug-metabolizing enzymes and transporters (see Drug interactions)