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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, et al

The unrefined plant extracts and isolated compounds have demonstrated a reduction in the amount of fat in the body, as well as a manifestation of their potential through the prevention of obesity caused by diet, thus making them fit for the development of the new, safer, and more potent anti-obesity treatments.[7] The renowned phytochemical constituents which include terpenoids, flavonoids, saponin, phenol, and alkaloids consist of key biological benefits

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The desired C2/3-diamino-group may be introduced via a two-step sequence involving an amination of C2-chloro- group with, for example, ammonia and reduction of C3-nitro group (via, e.g., hydrogenation) to give the precursor 16