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Increasing evidence suggests that TMAO may be involved in the progression of aortic valve sclerosis and calcification 29,30,31,32

Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity

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Or it can undergo P450 metabolism (most commonly CYP2E1 metabolism) to form NAPQI (N-Acetyl-p-benzoquinone imine), which can form a non-toxic product via glutathione conjugation (cysteine and mercapturic acid conjugates)