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Clinically, mitochondrial dysfunction symptoms include: dysautonomia (orthostasis, heat intolerance, POTS-like symptoms) muscle rigidity or tremors variable energy levels cognitive fog heightened reactivity to stress worsening symptoms during infection or inflammation poor exercise tolerance These same patterns appear in Parkinsons disease, neurodegenerative disorders, dysautonomia, and trauma-linked hyperarousal

It applies to all T4 medications.) As I mentioned, this is because levothyroxine contains the less-active but longer-acting T4 hormone, which needs to be converted to T3, the more active thyroid hormone, by our bodies