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Description

It was the kind of after-the-fact subgroup finding that launches a confirmatory trial and breaks hearts when that trial reads out

[PubMed: 2653201] 30

Practical considerations for KPV and eczema KPV is highly hydrophilic, which limits skin penetration in standard formulations

It is important to note that a highly electrophilic metabolite has a tendency to react with tissue nucleophilic groups such as -OH, -NH 2 and -SH and precipitate toxicities such as tissue necrosis, carcinogenesis, mutagenesis, teratogenesis, etc