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Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material

It is best known for its proposed role in tissue protection, angiogenesis, gastrointestinal repair, and tendon-ligament healing

It inhibits the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) and modulates macrophage polarization towards the M2 phenotype (reparative/anti-inflammatory)