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The role of CD38 in the tumor microenvironment on glioma progression was also investigated by comparing WT and CD38-deficient mouse models

Therefore, many monoclonal antibodies and small molecule inhibitors target the EGFR in a clinical setting, inhibiting EGFR and decelerating tumor growth (Seshacharyulu et al., 2012)

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Cells were harvested 24 or 48 h after stimulation