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Description

Overexpression of anti-apoptotic proteins of the BCL-2 family, such as BCL-2, BCL-xL and MCL-1, is frequently found in various cancers, including AML, thereby perturbing homeostasis of survival pathways and protecting cancer cells from death 8

GLP-1s ability to cross the blood-brain barrier, improve endothelial function, suppress inflammation, and protect neurons makes it a promising therapeutic target for PD [124, 125]