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Rotenone treated in vitro PD model showed impairment of lysosomal functions due to decreased NAD + /NADH and Sirt1 expression (Dong W et al., 2021)

Current PD-specific clinical interaction data are sparse

In addition, other enzymes also contribute to the cytosolic NADPH pool, such as IDHs, MEs, methylene-tetrahydrofolate dehydrogenases (MTHFDs), and 10-formyl-tetrahydrofolate dehydrogenases (FTHFDHs) (56, 111), all of which have both cytosolic and mitochondrial isozymes

Previous studies in myocardial ischemia have revealed that ischemia leads to a progressive loss of cholesterol from tissues and the sarcoplasmic and sarcoplasmic reticulum, accompanied by a significant increase in mitochondrial cholesterol content that is admixed explicitly to this membrane system [63]