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169 Molecular mediators that drive organ crosstalk Interorgan crosstalk among the kidney, heart, brain, adipose tissue, liver, skeletal muscle, pancreas, and intestine plays a pivotal role in the development of insulin resistance and -cell dysfunction, which are central to the progression of diabetic complications

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Protein disulfide isomerase modification and inhibition contribute to er stress and apoptosis induced by oxidized low density lipoproteins

Moreover, additional concerns were raised from preclinical studies suggesting that complete blockade of intratumoral blood flow could result in extreme hypoxia within the TME, which could accelerate local invasion and distant metastases of tumor cells and even induce severe immunosuppression within the TME 34