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Polyphenols from fruits and vegetables seem to be invaluable potential agents in neuro protection by virtue of their ability to influence and OH n by virtue of their ability to influence and modulate several cellular processes such as signaling, proliferation, apoptosis, redox balance and differentiation (Graf et al., 2005 and Hakim et al., 2000)

Moreover, Cathepsin K (CTSK), a well-known key enzyme highly expressed in the bone resorption process in RA, was analyzed to mark the osteoclast differentiation

Moreover, diet as the main microbiota influencing factor has been shown to influence arthritis 12,13

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