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Lovell JF

2016;5(8):15663 Jian Z, Li K, Song P, Zhu G, Zhu L, Cui T, Liu B, Tang L, Wang X, Wang G, Gao T, Li C

Glucose-6-phosphate dehydrogenase ( G6pdx ), the rate-limiting enzyme of the pentose phosphate pathway and critical generator of NAPDH, was identified by ChIP sequencing to be an NRF2 target gene in diethyl maleate-treated mouse liver and hepatoma cells (54)

These findings suggest that gut redox homeostasis is a key beneficiary of the restorative processes associated with sleep but that the gut may also actively mediate the systemic effects of sleep, including on longevity and aging (Vaccaro et al., 2020)