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Description

Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

This inhibition leads to an increase in H 2 O 2 production in hepatocytes, subsequently enhancing p38MAPK-CREB-Egr1 signaling-mediated DGAT2 promoter activity, SREBP1C-ACC1-mediated de novo lipogenesis, and ApoB100-mediated triglyceride transport into adipose tissues