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Iron plays a crucial role in ferroptosis, primarily by catalyzing the generation of ROS

To exclude the toxic influence of glycolysis products, lactate concentration was also measured daily to confirm that its accumulation remained at a relatively low level (not exceeding 25 mMol/l) that is known to be well-tolerated by cells (Hartley et al

The antioxidant enzymes (SOD, GRx and GPx) showed a decrease in their activities in preeclamptic women as compared with normal women, indicating the loss in their antioxidant capacity, whereas a significant increase in catalase activity showed its compensating regulatory role in response to the increased oxidative stress

These findings have since been repeated many times over 202,203,204,205