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In an alternative embodiment, mutations in biomarker nucleic acids from sample cells may be identified by changes in the pattern of restriction enzyme cleavage

Toxins 16:452

Phytochemistry, pharmacology, and medical uses of Oldenlandia (family Rubaceae): A review

Just how influential the method was can be seen from the fact that the paper publicising it was cited over 4,000 times over the next two decades (Jerne, 1981