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In macrocytic anaemia, the red blood cells are larger than normal

Upon illumination Rg increases from 42.1 (dark) to 52.2 (light), thus revealing an expansion of the protein, while I(0) remains almost unchanged (1.03 10 and 1.08 10 for dark and light state, respectively), indicating that the protein remains in its dimeric form

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Dosing is once daily, subcutaneously, with the timing chosen to align with natural lipolytic windows, typically before bed (to coincide with overnight fasting and growth hormone pulses) or first thing in the morning before training and food