glutathione reductase peroxidase pathway Glutathione-Related Enzymes and Proteins: A Review glutathione reductase mechanism of action

Ersoy 1 , (1)Weill Cornell Medicine, NY, (2)University of North Carolina at Chapel Hill Background: Y box-binding protein 1 (Ybx1), a nucleic acid-binding protein primarily known for its role in early development and stress-induced activation related to innate immunity and cancer, has also been implicated in metabolic disorders

Evenson D, Darzynkiewicz Z, Stainan-Coico L, Andreeff M , Traganos F, Melamed MR

Although the results so far are promising, most studies tend to use healthy cohorts as participants which limit the applicability of their findings to clinical populations

For co-expression experiments, transfections were performed with FLAG-LRRK2, YFP-ArfGAP1 (WT, phospho-null / phospho-mimic mutants) and DsRed plasmids at a 10:10:1 molar ratio