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Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes

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Paradoxically, DUSP16 knockdown in murine dendritic cells results in an elevation of antigen-presenting ability, leading to an increased proliferation of Th17 cells isolated from mice with the induction of experimental autoimmune uveitis [107]