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Under prolonged injury, inflammation, or mechanical stress, fibroblasts can phenotypically transform into myofibroblasts characterized by -SMA expression, synthesis of collagen-rich ECM, and fibroblast proliferation (88)

Huangyang P, Li F, Lee P, Nissim I, Weljie AM, Mancuso A, et al

Future research needs to focus on developing more targeted and efficient therapeutic strategies based on a deeper understanding of CAFs' biological characteristics, metabolic functions, and interactions with immune cells

doi: 10.1016/0026-0495(77)90088-9 [DOI] [PubMed] [Google Scholar] 151.Luo Y, Kawashima A, Ishido Y, Yoshihara A, Oda K, Hiroi N, et al