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2013;8:e57998

These mutations exacerbate ROS accumulation, leading to oxidative damage within the mitochondrial matrix, which further impairs antioxidant enzymes and diminishes the activity of key protective proteins such as SOD2 (Wang et al., 2018

Both tert-butylated hydroxyanisole (BHA) and 1,2-bis(2-pyridyl)ethylene (2PY-e) caused increased liver weight without any histopathological evidence of hepatocellular hypertrophy in rats (Makino et al