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The multi-target nature of many phytochemicals further complicates both mechanistic analysis and dose optimization (Figure 4)

The concerns surrounding hormone therapy extend beyond CVD and breast cancer, as it has also been correlated with an increased risk of venous thromboembolism, overall mortality, and cancer-related deaths (164, 165)

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Consequently, deciphering the contextual fate of glutamine is paramount for designing ferroptosis-targeted therapeutic interventions