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While safe at therapeutic doses of up to 4 grams per day for adults, acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for some 56,000 emergency room visits, 2,600 hospitalizations and nearly 500 deaths annually[2, 3]

980 It also affects Bcl-2 proteins, induces cell cycle arrest, and promotes autophagy

Crispin, J

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