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N., Pathophysiology and Treatment of Systemic Amyloidosis, Nature Reviews Nephrology 9, no

38,238,243 Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 K680 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex

However, for patients with subclinical autoimmunity and inflammation there is less clarity

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