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Third, the evidence hierarchy matters when justifying compound selection in research documentation

A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented

After absorption, SCFAs are directly transported to the liver via the portal vein where they can be converted into endogenous molecules such as cholesterol, fatty acids, and glucose, or function as signaling molecules (van der Beek et al., 2015)