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Emerging evidence indicates that SOX2 also plays an important role in maintaining MSC stemness and suppressing senescence

Nat Rev Microbiol 15:5563 Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

In cases requiring two salvage lines prior to HCT, patients were significantly younger (p = 0.041), received Bv more often as part of salvage chemotherapy (0.025) or post HCT consolidation (p = 0.1)

doi:10.1038/emm.2007.88 Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA et al (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate