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M.Barnholtz-SloanJ

TRAIL is a cytokine and produced in normal tissue

5.2 Flavoprotein functional defect-related mutation mechanisms In addition to genes directly involved in riboflavin uptake and metabolism, numerous inherited disorders arise from structural or functional defects in flavoproteins themselves

Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)