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Several vitamin deficiency states may directly or indirectly lead to muscle cramps

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Currently, bevacizumab, aflibercept, conbercept, and pegaptanib sodium have been studied in clinical studies as anti-VEGF medications for the treatment of DR ( Table 1 )

85 However, the rationale to support this observation is well characterised, since the hydrophobic tail of metformin can penetrate cell membranes, thereby altering potentials and hence displacing divalent cations such as calcium which can affect adhesion of a number of substances to the membrane