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whether (pro)drugs or nanocarriers reaches the target site in the brain (extra- or intracellular) and releases the parent drug at the target site at the adequate concentration to produce pharmacological effect

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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005

Dis ., Springer, New Jersey