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Moreover, simplified experimental paradigms often fail to capture the complex, multifactorial nature of human neurodegeneration, including chronic inflammation, metabolic dysfunction, and cumulative injury [569571]

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Treatment for B12 deficiency without neurological involvement: For patients with haematological manifestations only (macrocytic anaemia) or asymptomatic deficiency, the regimen is hydroxocobalamin 1mg intramuscularly three times weekly for two weeks (total of six injections), followed by maintenance of 1mg every three months for life