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F112 is shown in the conformations in crystal structures obtained without (blue) and with (magenta) (-)-catechin ( 12 ) and its surface is rendered transparently

10.1042/BJ20112131 Biochem

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Liver IRI is characterized by two interlinked phases: ischemia-induced hepatocyte injury, leading to the release of damage-associated molecular patterns, and subsequent recruitment of immune cells, initiating an inflammatory cascade that exacerbates hepatocyte damage