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Both enzymes are characterized by a low Km for ATP (at low M level) [18], thus permitting GSH biosynthesis to continue in hypoxic and/or energy-depleted conditions, and highlighting its significance for body homeostasis

FIGURE 1 Chronic ethanol impairs both basal and forskolin induced cAMP-dependent neurogenic differentiation of neural stem cells (NSC), by decreasing adenylyl cyclase (AC) mRNA, phosphodiesterases (PDEs) activity, as well as by downregulating Cyclic adenosine monophosphate (cAMP) production by reducing G-protein activation analyzed by [- 35 S] GTP binding assays