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however, as Meissner et al.s research demonstrates, red and purple phenotypes have distinctly different analytical profiles [67]

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In summary, the harmful effects of pepsin on the oesophageal mucosa include increased intercellular permeability, local accumulation of reactive oxygen species, oxidative stress, inflammation, mitochondrial injury and an increased risk of neoplastic development (Reference Kowalik and Krzeski28,Reference Bardhan, Strugala and Dettmar35,Reference Yu, Yu and Li38,Reference Jung and Park39)