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This weakens zonules, leading to bilateral lens dislocation in most cases, prevalent from infancy to later years

Unlike whole-body Gclc KO mice, liver-specific Gclc L-KO mice did not have any difference in survival or body weight following Gclc deletion (Fig

GAPDH, 18S rRNA, or a synthetic fragment of GFP mRNA (89 bases) was used as an internal control for data normalization

The half maximal inhibitory concentration (IC50) of zebularine is approximately seven-fold higher than that of 5AC (120 M vs 17.4 M, respectively) in human bladder cancer T24 cells, with a degradation rate lower than 7% within 48 h ( Zebularine also inhibits cytidine deaminase, which confers resistance to nucleoside analogs (Zhang et al., 2021) and liver HepG2 (Zhou et al., 2011)