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Furthermore, analysis of 80 SLE patients without cardiovascular disease identified global shifts in lipoprotein profiles, with mediumhigh-density lipoprotein (HDL) cholesterol esters most discriminatory for healthy controls, and small HDL phospholipids, small very low density lipoprotein (VLDL) phospholipids, very large VLDL-free cholesterol %, and intermediate-density lipoprotein phospholipids most associated with SLE classification [47]

Assays to test the influence of higher temperatures on the substrate preferences were performed at 70 C in SAH/SIH synthesis and cleavage directions with two selected model enzymes, Pfu SAHH (Euryarcheota) and Sac SAHH (Crenarchaeota)

Although PARP-1 has not been extensively studied in these contexts, existing data suggest a potential involvement that is worthy of further exploration

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