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Studies have shown that FIN56 can significantly reduce the survival rate of GBM cells (such as LN229 and U118 cells) by inducing ferroptosis, increasing lysosomal membrane permeability, inhibiting cell proliferation, and causing cell cycle arrest

How these variations impact systemic BA pools and the immune landscape of tumors, particularly those within the hepatobiliary-pancreatic system, and potentially extending to extra-intestinal sites where preliminary associations with BA exposure have been noted (190), needs to be clarified

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Accordingly, preferably excluded from the present invention are one or more polynucleotides consisting of a nucleotide sequence described by the general formula of a-b, where a is any integer between 1 to 2640 of SEQ ID NO:1, b is an integer between 15 to 2654, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO:1, and where b is greater than or equal to a+14