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Subsequently, IRF3 is phosphorylated by TBK1 in the complex, which promotes IRF3 homodimerization and translocation to the nucleus to further regulate the expression of a series of genes

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The presence of large, conserved stem loops and reports that 3X is a poor NS5B template in vitro 27 make it a potential target for unwinding by the NS3 helicase, thereby enabling initiation of NS5B-mediated () strand synthesis