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A five-day course of treatment with lidocaine has been found to reduce symptoms even after the end of treatment

Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies

In particular, appropriately timed light exposure is a powerful synchronizer for the SCN: morning daylight can help anchor the phase of the circadian clock, counteracting the tendency for phase advance, while minimizing bright light at night, especially blue-enriched light from screens, prevents melatonin suppression and preserves sleep quality (Voiculescu et al., 2016)

Statistics show that approximately 6080% of PD patients suffer from ENS dysfunction, including chronic constipation, drooling, and dysphagia, with significantly higher prevalence than in non-PD populations (42, 43)