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532 Apart from their roles above in redox balance and immune response, mitochondria also involve in proteostasis and other cellular functions that intensively interact with ER and nucleus

Viral infections and the subsequent systemic inflammation can compromise the integrity of the blood-brain barrier, allowing pro-inflammatory cytokines and activated immune cells to enter the brain

More interestingly, they also showed that many variations around this model exist depending on the initial conditions, revealing the complexity of OR regulation now translated to the concept of biased agonism