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The gastrointestinal evidence is arguably the strongest, given the peptide's endogenous origins

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This makes it particularly valuable in studies focused on athletic performance and endurance

Another line of evidence linking apoE4 with impaired autophagy was provided by another study that showed that apoE4 binds to the Coordinated Lysosomal Expression And Regulation (CLEAR) DNA motif and mediates the repression of the transcription factor EB (TFEB) that plays a crucial role in regulating various genes required for autophagy and lysosome biogenesis [69]