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The inhibition of these deleterious AT 1 receptor-mediated effects through ACE inhibitors or Ang receptor blockers (and more recently the direct renin inhibitor aliskiren) largely explains as to why the two former classes of antihypertensive drugs have become the gold standard of antihypertensive therapy

Drug Side Effect Mitigation Animal studies suggest BPC-157 may counteract adverse effects of certain pharmaceuticals, particularly NSAIDs, neuroleptics, and prokinetics

Published preclinical research has not identified nephrotoxicity as a concern with BPC-157

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