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Athletes and patients with active training schedules should avoid injecting into the thigh on heavy leg training days, as increased blood flow to active muscle can alter peptide absorption timing

Muscle cramps occur when muscle fibers contract suddenly and fail to relax immediately

Tirzepatide is injected subcutaneously into the abdomen, the upper outer thigh, or the back of the upper arm

However, several histological abnormalities were found in these mice, abnormalities that spanned several tissues and included chronic inflammation and hyperplasia of the gastric epithelium, calcification in the brain, testicular atrophy, loss of cytoplasmic granules in the striated duct cells of the salivary gland, and thinning of compact bone