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And, they reverse the hypermethylation of CpG islands in the promoter region of tumor suppressor gene by upregulating genes that are methylated due to fibrosis, such as the RASAL1 gene ( However, the disadvantages of 5AC and DAC are becoming increasingly apparent

Cp deficiency and mutations in copper-transporting genes such as ATP7B can cause abnormal metal distribution in the brain and induce (or exacerbate) neurodegenerative processes, including PD (168)

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