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Symptoms of peripheral arterial disease include: Painful cramping in the hips, thighs, or calf muscles (triggered by physical activity, such as climbing stairs) that disappears after resting a few minutes Numbness or weakness in the leg Coldness in the lower leg or foot when compared to the other leg Sores on the leg, feet, or toes that do not heal The skin of the leg changes color or becomes shiny The reduced hair growth or hair loss on the legs Reduced toenail growth No pulse or a weak pulse in the legs or feet Erectile dysfunction among male patients Painful cramping or aching in the arms triggered by tasks such as writing or knitting that disappears after a few minutes of rest Heart Arrhythmia Heart arrhythmia refers to an abnormal heartbeat

doi: 10.1038/ijo.2008.229

Control flasks were included to account for spontaneous dye decolorization

Le Y, Chen X, Wang L, He WY, He J, Xiong QM, Wang YH, Zhang L, Zheng XQ, Wang HB (2021) Chemotherapy-induced peripheral neuropathy is promoted by enhanced spinal insulin-like growth factor-1 levels via astrocyte-dependent mechanisms