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Despite our comprehensive search strategy, not all online databases were covered, and some articles, particularly non-English ones, may have been overlooked

This pathway begins with the cell membrane-bound cystine/glutamate antiporter, System Xc (27)

10.3390/ijms22168733 20 KimH

Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids