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Int J Clin Pract 2013

Pharmacological inhibition of JNK prevented 4-HNE-induced LC3-II formation, suggesting that 4-HNE triggered autophagic responses could be partly attributed to ER stress [155]

PubMed Database Peptide Research Literature

By keeping the solution refrigerated, you are essentially putting the brakes on these molecular interactions, preserving the integrity of the entire system for as long as possible