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They were reported to suppress ferroptosis in mouse embryonic fibroblasts ( Lpcat3 could also make mouse lung epithelial cells and embryonic cells more resistant to ferroptosis ( FIGURE 2 Lipoxygenases (LOXs) are iron-containing enzymes for cell membrane PLs oxidation, which are non-heme dioxygenases that catalyze the double oxygenation reaction of free and esterified PUFAs ( bis -allyl position at a PUFA to form a pentadienyl radical (L) ( 2 ) can take a hydrogen atom from the bis -allyl position of a PUFA (Yin et al., 2011)

Psychiatry 18, 425434

& Vicente, R